Article
An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae.
Genetics - 1 Mar 2014
Wilkening Stefan, Lin Gen, Fritsch Emilie S, Tekkedil Manu M, Anders Simon, Kuehn Raquel, Nguyen Michelle, Aiyar Raeka S, Proctor Michael, Sakhanenko Nikita A, Galas David J, Gagneur Julien, Deutschbauer Adam, Steinmetz Lars M
Abstract excerpt
Dissecting the molecular basis of quantitative traits is a significant challenge and is essential for understanding complex diseases. Even in model organisms, precisely determining causative genes and their interactions has remained elusive, due in part to difficulty in narrowing intervals to single genes and in detecting epistasis or linked quantitative trait loci. These difficulties are exacerbated by...
Topics
- Aneuploidy
- Chromosome Mapping
- Genetic Variation
- Genome, Fungal
- Genomics
- Mutation
- Phenotype
- Quantitative Trait Loci
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins