Pervasive context-dependent effects in the genetic architecture of complex and quantitative traits revealed by a powerful multiparent mapping population in yeast.

Abstract excerpt

The genetic dissection of complex traits remains a major challenge in basic and biomedical research, but is essential for understanding the molecular pathways that shape phenotypic variation and for developing predictive models of trait and disease susceptibility. Here, we leverage a novel multiparent mapping population of budding yeast, CYClones, comprising 9,344 haploid strains derived from eight genetically...

Topics

• Quantitative Trait Loci
• Saccharomyces cerevisiae
• Chromosome Mapping
• Phenotype
• Saccharomyces cerevisiae Proteins