Article
Genetic interactions contribute less than additive effects to quantitative trait variation in yeast.
Nature communications - 5 Nov 2015
Bloom Joshua S, Kotenko Iulia, Sadhu Meru J, Treusch Sebastian, Albert Frank W, Kruglyak Leonid
Abstract excerpt
Genetic mapping studies of quantitative traits typically focus on detecting loci that contribute additively to trait variation. Genetic interactions are often proposed as a contributing factor to trait variation, but the relative contribution of interactions to trait variation is a subject of debate. Here we use a very large cross between two yeast strains to accurately estimate the fraction of phenotypic...
Topics
- Chromosome Mapping
- Epistasis, Genetic
- Genetic Variation
- Genotype
- Phenotype
- Quantitative Trait Loci
- Saccharomyces cerevisiae