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Article

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast.

eLife - 11 Feb 2022

Nguyen Ba Alex N, Lawrence Katherine R, Rego-Costa Artur, Gopalakrishnan Shreyas, Temko Daniel, Michor Franziska, Desai Michael M

Abstract excerpt

Mapping the genetic basis of complex traits is critical to uncovering the biological mechanisms that underlie disease and other phenotypes. Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can now explain much of the observed heritability in many traits, allowing us to predict phenotype from genotype. However, constraints on power due to statistical...

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Identifiers

PMID: 35147078
DOI: 10.7554/eLife.73983
PMCID: PMC8979589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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