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Article

Genome-scale analysis of interactions between genetic perturbations and natural variation.

Nature communications - 18 May 2024

Hale Joseph J, Matsui Takeshi, Goldstein Ilan, Mullis Martin N, Roy Kevin R, Ville Christopher Ne, Miller Darach, Wang Charley, Reynolds Trevor, Steinmetz Lars M, Levy Sasha F, Ehrenreich Ian M

Abstract excerpt

Interactions between genetic perturbations and segregating loci can cause perturbations to show different phenotypic effects across genetically distinct individuals. To study these interactions on a genome scale in many individuals, we used combinatorial DNA barcode sequencing to measure the fitness effects of 8046 CRISPRi perturbations targeting 1721 distinct genes in 169 yeast cross progeny (or segregants). We...

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Share to CRISPR-Cas Systems
Share to DNA Barcoding, Taxonomic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

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Share to Genome, Fungal

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Share to Saccharomyces cerevisiae

Source

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Identifiers

PMID: 38762544
DOI: 10.1038/s41467-024-48626-1
PMCID: PMC11102447

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