Downregulation of CYP7B1 caused by lipotoxicity associates with the progression of non-alcoholic steatohepatitis

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with an incidence of >25% of the adult population. NAFLD ranges from benign simple steatosis to non-alcoholic steatohepatitis (NASH). However, its transition mechanisms underlying the pathogenesis remain to be clarified. The expression of Cyp7b1 gene is downregulated in the liver of leptin-deficient mice and methionine a...

Topics

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• Autophagy
• Cholesterol and Lipid Metabolism
• Diet, Metabolism, and Disease
• Endoplasmic Reticulum Stress and Disease
• Fibrosis
• Hepatocytes
• Liver Disease Diagnosis and Treatment
• Non-alcoholic Fatty Liver Disease

Identifiers and source

Literature Corpus work

588a7db7-8ddc-5a4d-b321-63025cb2b99a

DOI

10.1101/2023.05.10.539979