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Article

Hepatic Steatosis in the Mouse Model of Wilson Disease Coincides with a Muted Inflammatory Response.

The American journal of pathology - 1 Jan 2022

Gottlieb Aline, Dev Som, DeVine Lauren, Gabrielson Kathleen L, Cole Robert N, Hamilton James P, Lutsenko Svetlana

Abstract excerpt

Wilson disease (WND) is caused by inactivation of the copper transporter ATP7B and copper accumulation in tissues. WND presentations vary from liver steatosis to inflammation, fibrosis, and liver failure. Diets influence the liver phenotype in WND, but findings are inconsistent. To better understand the impact of excess calories on liver phenotype in WND, the study compared C57BL/6J Atp7b-/- and C57BL/6J mice fed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34627751
DOI: 10.1016/j.ajpath.2021.09.010
PMCID: PMC8759043

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