Article
Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality.
Cells - 5 Oct 2021
Evangelakos Ioannis, Schwinge Dorothee, Worthmann Anna, John Clara, Roeder Niklas, Pertzborn Paul, Behrens Janina, Schramm Christoph, Scheja Ludger, Heeren Joerg
Abstract excerpt
Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD). Here, we investigated whether CYP7B1 is involved in the etiology of MAFLD under conditions of low and high energy expenditure. For this, Cyp7b1-/- and wild type (WT) mice were fed a...
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