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Article

Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD

18 Jun 2012

Abstract excerpt

The problems of aging, obesity and a number of types of metabolic syndromes, including diabetes, are associated with a higher risk of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms of occurrence and development of NAFLD in humans remain unclear. Sterol regulatory element binding protein (SREBP)-1 is a transcription factor that is important in the development of NAFLD, which regulates the...

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PMID: 22710480
DOI: 10.3892/mmr.2012.953

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