Article
Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution.
eLife - 23 Sept 2020
Farhadifar Reza, Yu Che-Hang, Fabig Gunar, Wu Hai-Yin, Stein David B, Rockman Matthew, Müller-Reichert Thomas, Shelley Michael J, Needleman Daniel J
Abstract excerpt
The spindle shows remarkable diversity, and changes in an integrated fashion, as cells vary over evolution. Here, we provide a mechanistic explanation for variations in the first mitotic spindle in nematodes. We used a combination of quantitative genetics and biophysics to rule out broad classes of models of the regulation of spindle length and dynamics, and to establish the importance of a balance of cortical...
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