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Article

Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos.

Developmental cell - 1 Dec 2004

Walston Timothy, Tuskey Christina, Edgar Lois, Hawkins Nancy, Ellis Gregory, Bowerman Bruce, Wood William, Hardin Jeff

Abstract excerpt

How cells integrate the input of multiple polarizing signals during division is poorly understood. We demonstrate that two distinct Caenorhabditis elegans Wnt pathways contribute to the polarization of the ABar blastomere by differentially regulating its duplicated centrosomes. Contact with the C blastomere orients the ABar spindle through a nontranscriptional Wnt spindle alignment pathway, while a...

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PMID: 15572126
DOI: 10.1016/j.devcel.2004.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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