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Actin-based spindle positioning: new insights from female gametes

1 Jan 2014

Abstract excerpt

Asymmetric divisions are essential in metazoan development, where they promote the emergence of cell lineages. The mitotic spindle has astral microtubules that contact the cortex, which act as a sensor of cell geometry and as an integrator to orient cell division. Recent advances in live imaging revealed novel pools and roles of F-actin in somatic cells and in oocytes. In somatic cells, cytoplasmic F-actin is...

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PMID: 24413163
DOI: 10.1242/jcs.142711

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