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Microtubule stiffening by the doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in <i>Caenorhabditis elegans</i>

2024-12-02

Abstract excerpt

<h4>ABSTRACT</h4> In the Caenorhabditis elegans zygote, mutations in zyg-8 DCLK1 , the sole Doublecortin-family member, disrupt mitotic spindle positioning, as seen by immunofluorescence. Doublecortin proteins bind microtubules and are thought to stabilise or rigidify them. In the zygote, ZYG-8 only modestly affects microtubule growth and nucleation. We thus investigated whether these moderate dynamic perturba...

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Literature Corpus work
e50f8b1b-cca9-54c4-887f-b1afcce1b75e
DOI
10.1101/2024.11.29.624795
Open publication

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Microtubule stiffening by the doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in <i>Caenorhabditis elegans</i>DOI 10.1101/2024.11.29.624795
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