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Article

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts.

Developmental biology - 1 Jul 2008

Siller Karsten H, Doe Chris Q

Abstract excerpt

Mitotic spindle orientation in polarized cells determines whether they divide symmetrically or asymmetrically. Moreover, regulated spindle orientation may be important for embryonic development, stem cell biology, and tumor growth. Drosophila neuroblasts align their spindle along an apical/basal cortical polarity axis to self-renew an apical neuroblast and generate a basal differentiating cell. It is unknown...

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Identifiers

PMID: 18485341
DOI: 10.1016/j.ydbio.2008.03.018
PMCID: PMC2668259

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