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BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma

11 Feb 2025

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC), a metabolic disease originating from renal proximal convoluted tubule (PCT) epithelial cells, remains incompletely understood in terms of its initiating signaling events. Here, we identify γ-butyrobetaine hydroxylase 1 (BBOX1), a key enzyme in carnitine synthesis predominantly expressed in PCT cells, as a tumor suppressor in ccRCC. BBOX1 expression is lost during ccRCC...

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PMID: 39934163
DOI: 10.1038/s41467-025-56955-y

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