Genetic and metabolic hallmarks of clear cell renal cell carcinoma.

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by deregulated hypoxia-inducible factor signaling, mutation of several key chromatin modifying enzymes, and numerous alterations in cellular metabolism. Pre-clinical studies have historically been limited to cell culture models, however, the identification of critical tumor suppressors and oncogenes from large-scale patient sequencing data has...

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• Carcinoma, Renal Cell
• Disease Models, Animal
• Genetic Variation
• Glucose
• Kidney Neoplasms