Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive molecular characterization of clear cell renal cell carcinoma.

Nature - 4 Jul 2013

Abstract excerpt

Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, PBRM1). We surveyed more than 400 tumours using different genomic platforms and identified 19 significantly mutated genes. The PI(3)K/AKT pathway was recurrently mutated, suggesting this pathway as a potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyl-CoA Carboxylase
Share to AMP-Activated Protein Kinases
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Citric Acid Cycle

Share to Histone-Lysine N-Methyltransferase

Share to Pentose Phosphate Pathway

Share to RNA, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 23792563
DOI: 10.1038/nature12222
PMCID: PMC3771322

Genes

PBRM1
GRB10
PTEN
SETD2
SMARCA4
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive molecular characterization of clear cell renal cell carcinoma.PMID 23792563Read ↗

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

Genetic and metabolic hallmarks of clear cell renal cell carcinoma.Semantic proximity Read ↗

Integrated molecular analysis of clear-cell renal cell carcinoma.Semantic proximity Read ↗

Molecular and Metabolic Basis of Clear Cell Carcinoma of the KidneySemantic proximity Read ↗

Diagnostic and Prognostic Biomarkers in Renal Clear Cell CarcinomaSemantic proximity Read ↗

Diagnostic and Prognostic Biomarkers in Renal Clear Cell CarcinomaSemantic proximity Read ↗

PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genesSemantic proximity Read ↗

The molecular biology of renal cell carcinoma.Semantic proximity Read ↗

Molecular genetics of clear-cell renal cell carcinoma.Semantic proximity Read ↗

PBRM1, SETD2 and BAP1 - the trinity of 3p in clear cell renal cell carcinoma.Semantic proximity Read ↗

Genomic Profiling and Molecular Characterization of Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.