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Driver-Independent Suppression of Nuclear-Encoded Mitochondrial Metabolism at Stage I in Clear Cell Renal Cell Carcinoma: A Multi-Cohort Transcriptomic Analysis

2026-05-22

Abstract excerpt

<title>Abstract</title> <p>Clear cell renal cell carcinoma (ccRCC) exhibits near-universal VHL tumour suppressor loss, yet whether suppression of mitochondrial oxidative metabolism represents an obligate event in tumour initiation remains unresolved. We systematically analysed 1,074 nuclear-encoded mitochondrial genes from MitoCarta 3.0 in TCGA-KIRC (529 primary tumours, 72 normal-adjacent samples) using Mann-Whi...

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Literature Corpus work: 37a2dcc8-ea68-58ab-9641-1bdb77124b76
DOI: 10.21203/rs.3.rs-9772400/v1

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