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Article

The molecular code of kidney cancer: A path of discovery for gene mutation and precision therapy.

Molecular aspects of medicine - 1 Feb 2025

Xie Deqian, Li Guandu, Zheng Zunwen, Zhang Xiaoman, Wang Shijin, Jiang Bowen, Li Xiaorui, Wang Xiaoxi, Wu Guangzhen

Abstract excerpt

Renal cell carcinoma (RCC) is a malignant tumor with highly heterogeneous and complex molecular mechanisms. Through systematic analysis of TCGA, COSMIC and other databases, 24 mutated genes closely related to RCC were screened, including VHL, PBRM1, BAP1 and SETD2, which play key roles in signaling pathway transduction, chromatin remodeling and DNA repair. The PI3K/AKT/mTOR signaling pathway is particularly...

Topics

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Carcinoma, Renal Cell
MTOR gene
PBRM1 gene
Kidney Neoplasms
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

Signal Transduction

Source

Identifiers

PMID: 39746268
DOI: 10.1016/j.mam.2024.101335

Genes

BAP1
MTOR
PBRM1
PIK3CA
PTEN
SDHB
SETD2
TFEB
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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