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The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis

19 Nov 2015

Abstract excerpt

Oncocytomas are predominantly benign neoplasms possessing pathogenic mitochondrial mutations and accumulation of respiration-defective mitochondria, characteristics of unknown significance. Using exome and transcriptome sequencing, we identified two main subtypes of renal oncocytoma. Type 1 is diploid with CCND1 rearrangements, whereas type 2 is aneuploid with recurrent loss of chromosome 1, X or Y, and/or 14 and...

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PMID: 26655904
DOI: 10.1016/j.celrep.2015.10.059

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