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ABCA7 and Pathogenic Pathways of Alzheimer’s Disease

5 Feb 2018

Abstract excerpt

The ATP-binding cassette (ABC) reporter family functions to regulate the homeostasis of phospholipids and cholesterol in the central nervous system, as well as peripheral tissues. ABCA7 belongs to the A subfamily of ABC transporters, which shares 54% sequence identity with ABCA1. While ABCA7 is expressed in a variety of tissues/organs, including the brain, recent genome-wide association studies (GWAS) have...

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PMID: 29401741
DOI: 10.3390/brainsci8020027

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