Article
Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma.
Nature communications - 29 Jan 2025
van Hijfte Levi, Geurts Marjolein, de Heer Iris, Ghisai Santoesha A, Balcioglu Hayri E, Hoogstrate Youri, Vallentgoed Wies R, Head Rania, Luning Rosa, van den Bosch Thierry, Westerman Bart, Wesseling Pieter, Joyce Johanna A, French Pim, Debets Reno
Abstract excerpt
Isocitrate dehydrogenase 1/2 mutant (IDHmt) astrocytoma is considered a T cell-deprived tumor, yet little is known regarding the phenotypes underlying T cell exclusion. Using bulk, single nucleus and spatial RNA and protein profiling, we demonstrate that a distinct spatial organization underlies T cell confinement to the perivascular space (T cell cuff) in IDHmt astrocytoma. T cell cuffs are uniquely...
Read the complete abstract on PubMedTopics
- Astrocytoma
- Humans
- Isocitrate Dehydrogenase
- T-Lymphocytes
- Mutation