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Article

Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas.

Neuro-oncology - 5 Dec 2024

Gupta Pravesh, Dang Minghao, Oberai Shivangi, Migliozzi Simona, Trivedi Rakesh, Kumar Gayatri, Peshoff Mekenzie, Milam Nancy, Ahmed Aml, Bojja Krishna, Tran Tuan M, Gumin Joy, Kamiya-Matsuoka Carlos, Huse Jason, Cox Kathryn, Li Jianzhuo, Shehwana Huma, Sheth Sameer A, Saxon Rodriguez, Baohua Sun, Parker Kerrigan Brittany, Maheshwari Atul, Parra Cuentas Edwin Roger, Navin Nicholas E, Heimberger Amy B, Lang Frederick F, Iavarone Antonio, Clise-Dwyer Karen, Wang Linghua, Bhat Krishna P

Abstract excerpt

BACKGROUND: Human gliomas are classified using isocitrate dehydrogenase (IDH) status as a prognosticator; however, the influence of genetic differences and treatment effects on ensuing immunity remains unclear. METHODS: In this study, we used sequential single-cell transcriptomics on 144 678 and spectral cytometry on over 2 million immune cells encompassing 48 human gliomas to decipher their immune landscape....

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CD8-Positive T-Lymphocytes
Glioma
Isocitrate Dehydrogenase
Lymphocytes, Tumor-Infiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

Single-Cell Analysis

Tumor Microenvironment

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Identifiers

PMID: 39126294
DOI: 10.1093/neuonc/noae139
PMCID: PMC11630528

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