Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma.

Cellular oncology (Dordrecht, Netherlands) - 29 Dec 2025

Chen Wei, Zheng Min, An Jia-Yin, Huang Guo-Hao, Liu Jing-Peng, Yang Lin, Ren Peng, Wang Ting-Ting, Hugnot Jean-Philippe, Lv Sheng-Qing

Abstract excerpt

INTRODUCTION: (Isocitrate dehydrogenase) IDH-mutant astrocytoma is classified as World Health Organization (WHO) grade 2-4 and is second only to IDH wild-type glioblastoma in the incidence of adult glioma. However, few studies use single-cell and spatial transcriptome sequencing to analyze its malignant progression. METHODS: Intraoperative navigation and yellow fluorescence visualization were utilized to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to Isocitrate Dehydrogenase

Share to Neoplasm Grading

Share to Single-Cell Analysis

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 41460424
DOI: 10.1007/s13402-025-01139-5
PMCID: PMC12748311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma.PMID 41460424Read ↗

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seqSemantic proximity Read ↗

Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME.Semantic proximity Read ↗

Acquired genetic and cell-state changes in IDH-mutant glioma progression.Semantic proximity Read ↗

Single‐cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild‐type gliomaSemantic proximity Read ↗

Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk modelSemantic proximity Read ↗

Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas.Semantic proximity Read ↗

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.Semantic proximity Read ↗

Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like stateSemantic proximity Read ↗

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade gliomaSemantic proximity Read ↗

Multi◻region whole◻genome and transcriptomic profiling uncovers plastic, subclone◻linked cell states in high◻grade diffuse astrocytomasSemantic proximity Read ↗

Multi-omics integrative analysis of the glioma microenvironment reveals IDH-dependent cellular communication and prognostic signaturesSemantic proximity Read ↗

Surveying Brain Tumor Heterogeneity by Single-Cell RNA Sequencing of Multi-sector BiopsiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.