Article
Single-cell profiling of peripheral and local immune compartments reveal unique genotype-independent prognostic immune signatures across isocitrate dehydrogenase-stratified glioma.
Neuro-oncology - 1 Jan 2026
Sussman Jonathan H, Cillo Anthony R, Kohli Sajeev, Cardello Carly, Patterson Jonathan, Akca Ebrar, Angione Angelo, Moon David, Krueger Katharine, Ghamari Ali, Xu Emily, Xu Jessica, Tarbay Antonio C, Li Alex, Budihal Bhargavi R, Zhang Xiaoran, Elghawy Omar, Panek Wojciech K, Rajappa Prajwal, Tan Kai, Vignali Dario A A, Bruno Tullia C, Amankulor Nduka M
Abstract excerpt
BACKGROUND: Solid tumor immune suppression requires cooperation of tumor cells, local immune cells, peripheral circulating immune cells, and evolution of immune cell trajectories between peripheral and local environments. This study addresses a significant knowledge gap by characterizing peripheral and local immune environments in isocitrate dehydrogenase (IDH) Mutant (IDH-Mut) and IDH wildtype (IDH-WT) gliomas...
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