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Article

A map of the spatial distribution and tumour-associated macrophage states in glioblastoma and grade 4 IDH-mutant astrocytoma.

The Journal of pathology - 1 Oct 2022

Yin Wen, Ping Yi-Fang, Li Fei, Lv Sheng-Qing, Zhang Xiao-Ning, Li Xue-Gang, Guo Ying, Liu Qing, Li Tian-Ran, Yang Liu-Qing, Yang Kai-Di, Liu Yu-Qi, Luo Chun-Hua, Luo Tao, Wang Wen-Ying, Mao Min, Luo Min, He Zhi-Cheng, Cao Mian-Fu, Chen Cong, Miao Jing-Ya, Zeng Hui, Wang Chao, Zhou Lei, Yang Ying, Yang Xi, Wang Qiang-Hu, Feng Hua, Shi Yu, Bian Xiu-Wu

Abstract excerpt

Tumour-associated macrophages (TAMs) abundantly infiltrate high-grade gliomas and orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH)-differential grade 4 gliomas remains largely unknown. This study aimed to dissect the transcriptional states, spatial distribution, and clinicopathological significance of distinct monocyte-derived TAM (Mo-TAM) and microglia-derived TAM (Mg-TAM)...

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Identifiers

PMID: 35723032
DOI: 10.1002/path.5984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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