Article
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
30 Mar 2017
Abstract excerpt
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)-mutant gliomas by combining 14,226 single-cell RNA sequencing (RNA-seq) profiles from 16 patient samples with bulk RNA-seq profiles from 165 patient samples. Differences in bulk profiles between...
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