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Plasma β-hydroxybutyrate concentration, genetic risk, and the incidence of Alzheimer's disease: A prospective study of 261,933 participants.

Clinical nutrition (Edinburgh, Scotland) - 1 Mar 2025

Kim Ha-Na, Lee Ji Hyun, Boscardin John, Newman John C

Abstract excerpt

BACKGROUND: We investigated whether plasma β-hydroxybutyrate levels, a genetic risk score for Alzheimer's disease, and their interaction are associated with incident Alzheimer's disease. METHODS: Using data from the UK Biobank-a population-based cohort study of adults aged 40-69 years, we assessed associations between baseline plasma β-hydroxybutyrate level, genetic risk score for Alzheimer's disease, and...

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PMID: 39854811
DOI: 10.1016/j.clnu.2025.01.007

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