Article

3-Hydroxybutyrate, A Metabolite in Sustaining Neuronal Cell Vitality: A Mendelian Randomization and in Vitro Experimentation

2024-11-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Recent research has implicated mitochondrial DNA copy number (mtDNA-CN) and Tau protein levels in the blood as potential biomarkers for early Alzheimer's disease (AD) risk assessment, correlating with metabolite profiles. However, intermediary metabolites mediating these associations remain elusive. <bold>Methods </bold>Employing a two-sample and a mediation Mend...

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Literature Corpus work: eb1b8415-032f-5d18-b988-1100dac2a8a1
DOI: 10.21203/rs.3.rs-5295282/v1

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