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Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank.

Alzheimer's research & therapy - 11 May 2024

Zhang Tingjing, An Yu, Shen Zhenfei, Yang Honghao, Jiang Jinguo, Chen Liangkai, Lu Yanhui, Xia Yang

Abstract excerpt

BACKGROUND: Previous studies on the associations between serum urate levels and neurodegenerative outcomes have yielded inconclusive results, and the causality remains unclear. This study aimed to investigate whether urate levels are associated with the risks of Alzheimer's disease and related dementias (ADRD), Parkinson's disease (PD), and neurodegenerative deaths. METHODS: This prospective study included...

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Identifiers

PMID: 38730474
DOI: 10.1186/s13195-024-01476-x
PMCID: PMC11088014

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