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Longitudinal analysis of UK Biobank participants suggests age and APOE-dependent alterations of energy metabolism in development of dementia

2022-02-26

Abstract excerpt

Experimental models shows that bioenergetic homeostasis changes with increasing age based on apolipoprotein E ( APOE ) gene. However, such link with dementia remains unclear in population. We used H 1 -NMR metabolome in blood from 118,021 random-selected participants in UK Biobank (n=118,021 individuals), and identified 56 metabolites associated with the risk of dementia. In the participants without developing dem...

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Literature Corpus work
5a32c862-1a4e-5bbc-aaba-98bd860eb170
DOI
10.1101/2022.02.25.22271530
Open publication

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Longitudinal analysis of UK Biobank participants suggests age and APOE-dependent alterations of energy metabolism in development of dementiaDOI 10.1101/2022.02.25.22271530
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