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Article

Association of genetic risk score for Alzheimer's disease with late-life body mass index in all of us: Evaluating reverse causation.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2025

Choi Minhyuk, Zimmerman Scott C, Buto Peter T, Wang Jingxuan, Brenowitz Willa D, Hoffmann Thomas J, Hazzouri Adina Zeki Al, Kezios Katrina, Glymour M Maria

Abstract excerpt

INTRODUCTION: Decreases in body mass index (BMI) may be early consequences of Alzheimer's disease (AD) pathophysiological changes. Previous research in the UK Biobank estimated that AD-related genes began affecting BMI around age 47. We assessed whether this result could be replicated using longitudinal data in an independent cohort. METHODS: Using All of Us (AOU) (N = 197,619, aged 30+) data, we estimated linear...

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PMID: 40189781
DOI: 10.1002/alz.14598
PMCID: PMC11972977

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