Back to search

Article

Effects of genetic liability to Alzheimer’s disease on circulating metabolites across the life course

2022-03-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Alzheimer’s disease (AD) has several known genetic determinants, yet the mechanisms through which they lead to disease onset remain poorly understood. This study aims to estimate the effects of genetic liability to AD on plasma metabolites measured at seven different stages across the life course. <h4>Methods</h4> Genetic and metabolomic data from 5,648 offspring from the Avon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
df034dd6-d386-542b-9032-ae0f9d415354
DOI
10.1101/2022.03.24.22272867
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Effects of genetic liability to Alzheimer’s disease on circulating metabolites across the life courseDOI 10.1101/2022.03.24.22272867
Life course plasma metabolomic signatures of genetic liability to Alzheimer's disease.Semantic proximity
Alzheimer's disease polygenic risk's association with all-cause dementia through the plasma metabolome in the UK Biobank study.Semantic proximity
The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomizationSemantic proximity
Genetic risk for Alzheimer’s disease, and differential trajectories in circulating blood biomarkers in UK Biobank (n=17,817)Semantic proximity
Genetic regulation of the metabolome differs by sex, Alzheimer's disease stage, and plasma biomarker status.Semantic proximity
Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.Semantic proximity
The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization.Semantic proximity
Genetic Regulation of the Metabolome Differs by Sex, Alzheimer’s Disease Stage, and Plasma Biomarker StatusSemantic proximity
Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life.Semantic proximity
Genetic Associations Between Modifiable Risk Factors and Alzheimer DiseaseSemantic proximity
Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early lifeSemantic proximity
Investigating Causal Relations Between Circulating Metabolites and Alzheimer’s Diseases: A Mendelian Randomization StudySemantic proximity
Select a neighboring publication to make it the new centre.