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Article

Probing the properties of PTEN specific botulinum toxin type E mutants.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Dec 2025

Schiavone Giorgia, Richter Sandy, Henke Tina, Koch Ineke, Thies Linda, Klöpper Fiete, Megighian Aram, Pirazzini Marco, Binz Thomas

Abstract excerpt

Botulinum neurotoxins (BoNT) are established biopharmaceuticals for neuromuscular and secretory conditions based on their ability to block neurotransmitter release from neurons by proteolyzing specific soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Recently, a mutant catalytic domain of serotype E (LC/E) exhibiting 16 mutations was reported to cleave the phosphatase and...

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Share to Botulinum Toxins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39849213
DOI: 10.1007/s00702-025-02879-2
PMCID: PMC12669263

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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