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Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid.

Scientific reports - 2 Feb 2022

Nowakowska Maria B, Selby Katja, Przykopanski Adina, Krüger Maren, Krez Nadja, Dorner Brigitte G, Dorner Martin B, Jin Rongsheng, Minton Nigel P, Rummel Andreas, Lindström Miia

Abstract excerpt

Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a multipurpose therapeutic. Nevertheless, as the most potent natural toxin, BoNT is classified as a Select Agent in the US, placing C. botulinum research under stringent governmental regulations. The...

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Identifiers

PMID: 35110559
DOI: 10.1038/s41598-022-05008-1
PMCID: PMC8810926

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