Article
Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
PLoS biology - 1 Mar 2020
Yin Linxiang, Masuyer Geoffrey, Zhang Sicai, Zhang Jie, Miyashita Shin-Ichiro, Burgin David, Lovelock Laura, Coker Shu-Fen, Fu Tian-Min, Stenmark Pål, Dong Min
Abstract excerpt
Botulinum neurotoxins (BoNTs) are a family of bacterial toxins with seven major serotypes (BoNT/A-G). The ability of these toxins to target and bind to motor nerve terminals is a key factor determining their potency and efficacy. Among these toxins, BoNT/B is one of the two types approved for medical and cosmetic uses. Besides binding to well-established receptors, an extended loop in the C-terminal...
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