Article

Botulinum toxin intoxication requires retrograde transport and membrane translocation at the ER in RenVM neurons

2023-10-20

Abstract excerpt

Botulinum neurotoxin A (BoNT/A) is a highly potent proteolytic toxin specific for neurons with numerous clinical and cosmetic uses. After uptake at the synapse, the protein is proposed to translocate from synaptic vesicles to cytosol through a self-formed channel. Surprisingly, we found that after intoxication proteolysis of a fluorescent reporter occurs in the neuron soma first and then centrifugally in neurites....

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Literature Corpus work: 339fb5ee-eca6-5146-a941-d5dc7244a7ca
DOI: 10.1101/2023.10.17.562749

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Botulinum toxin intoxication requires retrograde transport and membrane translocation at the ER in RenVM neuronsDOI 10.1101/2023.10.17.562749Read

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