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Article

Rational design of botulinum neurotoxin A1 mutants with improved oxidative stability.

Toxicon : official journal of the International Society on Toxinology - 1 Jun 2018

López de la Paz Manuela, Scheps Daniel, Jurk Marcel, Hofmann Fred, Frevert Jürgen

Abstract excerpt

Botulinum neurotoxins (BoNTs) are the most potent toxic proteins to mankind known but applied in low doses trigger a localized muscle paralysis that is beneficial for the therapy of several neurological disorders and aesthetic treatment. The paralytic effect is generated by the enzymatic activity of the light chain (LC) that cleaves specifically one of the SNARE proteins responsible for neurotransmitter...

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Identifiers

PMID: 29042311
DOI: 10.1016/j.toxicon.2017.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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