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New Engineered-Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E.

Immunology - 1 Jan 2025

Wang Jingrong, Lu Jiansheng, Li Bolin, Liu Xiaoyu, Wang Rong, Du Peng, Yu Shuo, Yang Zhixin, Yu Yunzhou

Abstract excerpt

Botulinum neurotoxins (BoNTs), including serotypes A and E, are potent biotoxins known to cause human poisoning. In addition to the critical protective antigen found in the full BoNT molecule, the receptor binding domain (Hc domain), BoNTs also harbour another essential protective antigen-the light chain-translocation domain (L-HN domain). Leveraging these pivotal protective antigens, we genetically engineered a...

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PMID: 39354747
DOI: 10.1111/imm.13867

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