Article

Additive Multilocus Burden and Epistatic Interactions Improves Genetic Risk Predictions for Complex Diseases

2026-08-14

Abstract excerpt

Polygenic risk scores (PRS) assume additive SNP effects, yet genetic risk also arises from interactions between loci and environmental factors that contribute to broad-sense heritability. We developed an extended PRS (ePRS) framework for type 2 diabetes (T2D) that incorporates locus-by-locus non-additive effects beyond those captured by additive single-locus PRS or linkage disequilibrium (LD) tagging. These were m...

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Literature Corpus work: 464f150e-b3d4-50e7-b38e-b021ca953faa
DOI: 10.64898/2026.08.12.26360291

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