Article

Deep Learning captures the effect of epistasis in multifactorial diseases

2024-03-22

Abstract excerpt

<title>Abstract</title> <p>Background Polygenic risk score (PRS) prediction is widely used to assess the risk of diagnosis and progression of many diseases. Routinely, the weights of individual SNPs are estimated by the linear regression model that assumes independent and linear contribution of each SNP to the phenotype. However, for complex multifactorial diseases such as Alzheimer's disease, diabetes, cardiova...

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Literature Corpus work: fe764798-5432-5e4d-bd7f-229bcf70e77b
DOI: 10.21203/rs.3.rs-4023454/v1

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