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Article

Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts.

American journal of human genetics - 6 Feb 2025

Wei Julong, Resztak Justyna A, Ranjbaran Ali, Alazizi Adnan, Mair-Meijers Henriette E, Slatcher Richard B, Zilioli Samuele, Wen Xiaoquan, Luca Francesca, Pique-Regi Roger

Abstract excerpt

cis-regulatory elements (CREs) control gene transcription dynamics across cell types and in response to the environment. In asthma, multiple immune cell types play an important role in the inflammatory process. Genetic variants in CREs can also affect gene expression response dynamics and contribute to asthma risk. However, the regulatory mechanisms underlying control of transcriptional dynamics across different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

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Share to Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 39814021
DOI: 10.1016/j.ajhg.2024.12.017
PMCID: PMC11866969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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