Article

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations

2025-02-17

Abstract excerpt

<h4>Background</h4> Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset asthma (COA). However, the causal variants, regulatory elements, and effector genes at these loci are largely unknown. <h4>Methods</h4> We performed heritability enrichment analysis to determine relevant cell types for AOA and COA, respectively. Next, we fine-mapped pu...

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Literature Corpus work: 397c2bec-c47a-5611-a3b1-cc227abcb7b0
DOI: 10.1101/2025.02.11.25322088

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