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Article

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.

Genome medicine - 10 Apr 2025

Zhong Xiaoyuan, Mitchell Robert, Billstrand Christine, Thompson Emma E, Sakabe Noboru J, Aneas Ivy, Salamone Isabella M, Gu Jing, Sperling Anne I, Schoettler Nathan, Nóbrega Marcelo A, He Xin, Ober Carole

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset asthma (COA). However, the causal variants, regulatory elements, and effector genes at these loci are largely unknown. METHODS: We performed heritability enrichment analysis to determine relevant cell types for AOA and COA, respectively. Next, we fine-mapped putative causal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40205616
DOI: 10.1186/s13073-025-01459-z
PMCID: PMC11983851

Genes

TNFSF4

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