Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2.

doi:10.1016/j.xgen.2024.100556

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Article

Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2.

Cell genomics - 8 May 2024

Littleton Sheridan H, Trang Khanh B, Volpe Christina M, Cook Kieona, DeBruyne Nicole, Maguire Jean Ann, Weidekamp Mary Ann, Hodge Kenyaita M, Boehm Keith, Lu Sumei, Chesi Alessandra, Bradfield Jonathan P, Pippin James A, Anderson Stewart A, Wells Andrew D, Pahl Matthew C, Grant Struan F A

Abstract excerpt

The ch12q13 locus is among the most significant childhood obesity loci identified in genome-wide association studies. This locus resides in a non-coding region within FAIM2; thus, the underlying causal variant(s) presumably influence disease susceptibility via cis-regulation. We implicated rs7132908 as a putative causal variant by leveraging our in-house 3D genomic data and public domain datasets. Using a...

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PMID: 38697123
DOI: 10.1016/j.xgen.2024.100556
PMCID: PMC11099382

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FAIM2

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