HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.

doi:10.1016/j.immuni.2016.08.016

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HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.

Immunity - 20 Sept 2016

Steichen Jon M, Kulp Daniel W, Tokatlian Talar, Escolano Amelia, Dosenovic Pia, Stanfield Robyn L, McCoy Laura E, Ozorowski Gabriel, Hu Xiaozhen, Kalyuzhniy Oleksandr, Briney Bryan, Schiffner Torben, Garces Fernando, Freund Natalia T, Gitlin Alexander D, Menis Sergey, Georgeson Erik, Kubitz Michael, Adachi Yumiko, Jones Meaghan, Mutafyan Andrew A, Yun Dong Soo, Mayer Christian T, Ward Andrew B, Burton Dennis R, Wilson Ian A, Irvine Darrell J, Nussenzweig Michel C, Schief William R

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope (Env) trimer are the most common bnAbs induced during infection, making them promising leads for vaccine design. Wild-type Env glycoproteins lack detectable affinity for supersite-bnAb germline precursors and are therefore unsuitable immunogens to prime supersite-bnAb responses. We employed mammalian cell surface display to...

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Identifiers

PMID: 27617678
DOI: 10.1016/j.immuni.2016.08.016
PMCID: PMC5040827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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