Article

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

2025-10-06

Abstract excerpt

A major obstacle confronting HIV-1 vaccine and cure research is the lack of an outbred animal model for rapid and consistent induction of broadly neutralizing antibodies (bNAbs). We designed an epitope-focused simian-human immunodeficiency virus (SHIV.5MUT) that elicited broad and potent V3-glycan-targeted antibodies within a year of infection in 14 of 22 macaques compared with 0 of 14 control animals. SHIV.5MUT e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92a45fb9-99ce-5462-9a82-412f0eeecde3
DOI: 10.1101/2025.10.06.680687

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen DesignDOI 10.1101/2025.10.06.680687Read

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody <i>In Vitro</i> Improves Protection against Lentiviral Infection <i>In Vivo</i>Semantic proximity Read

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus MacaqueSemantic proximity Read

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal ModelsSemantic proximity Read

Rapid development of glycan-specific, broad, and potent anti–HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaqueSemantic proximity Read

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.Semantic proximity Read

<scp>HIV</scp>‐1 neutralizing antibodies: understanding nature's pathwaysSemantic proximity Read

Determinants of HIV-1 broadly neutralizing antibody induction.Semantic proximity Read

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunizationSemantic proximity Read

Harnessing the protective potential of HIV-1 neutralizing antibodiesSemantic proximity Read

Catch Me If You Can--The Race Between HIV and Neutralizing Antibodies.Semantic proximity Read

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection.Semantic proximity Read

Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopesSemantic proximity Read