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A gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genes

2020-07-14

Abstract excerpt

<h4>Motivation</h4> Transcriptome-wide association studies (TWAS) have successfully facilitated the discovery of novel genetic risk loci for many complex traits, including late-onset Alzheimer’s disease (AD). However, most existing TWAS methods rely only on gene expression and ignore epigenetic modification (i.e., DNA methylation) and functional regulatory information (i.e., enhancer-promoter interactions), both...

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Literature Corpus work
a61ffd8e-750c-5af9-b5dc-e2a8c1895ceb
DOI
10.1101/2020.07.13.201376
Open publication

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A gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genesDOI 10.1101/2020.07.13.201376
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