Article

Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures

2025-03-18

Abstract excerpt

Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late-onset Alzheimer’s disease contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances in molecular subtyping through proteomic and transcriptomic profiling reveal distinct patient subgroups, highlighting disease complexity beyond amyloid-beta plaques and tau tangles. This insight undersco...

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Literature Corpus work: 20a33431-fc07-5265-b0f3-278593146451
DOI: 10.1101/2025.03.15.643144

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