Article
CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells.
Nucleic acids research - 11 Mar 2015
Chang Fiona T M, Chan F Lyn, R McGhie James D, Udugama Maheshi, Mayne Lynne, Collas Philippe, Mann Jeffrey R, Wong Lee H
Abstract excerpt
Human ALT cancers show high mutation rates in ATRX and DAXX. Although it is well known that the absence of ATRX/DAXX disrupts H3.3 deposition at heterochromatin, its impact on H3.3 deposition and post-translational modification in the global genome remains unclear. Here, we explore the dynamics of phosphorylated H3.3 serine 31 (H3.3S31ph) in human ALT cancer cells. While H3.3S31ph is found only at pericentric...
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