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Article

CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells.

Nucleic acids research - 11 Mar 2015

Chang Fiona T M, Chan F Lyn, R McGhie James D, Udugama Maheshi, Mayne Lynne, Collas Philippe, Mann Jeffrey R, Wong Lee H

Abstract excerpt

Human ALT cancers show high mutation rates in ATRX and DAXX. Although it is well known that the absence of ATRX/DAXX disrupts H3.3 deposition at heterochromatin, its impact on H3.3 deposition and post-translational modification in the global genome remains unclear. Here, we explore the dynamics o...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25690891
DOI: 10.1093/nar/gkv104
PMCID: PMC4357709

Genes

ATRX
DAXX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25690891-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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